Mar 23, 2022 8:15 AM
thyssenkrupp wins an order for a pharma-grade SFE (Supercritical Fluid Extraction) plant for solids extraction
Uhde High Pressure Technologies delivers modular high-end plant
Pharmaceutical compliant hygienic design and control system
Environmentally-friendly extraction using CO2 as solvent
thyssenkrupp’s Uhde High Pressure Technologies won an order from a company in the specialty chemicals sector to fabricate and supply a pharma-grade Supercritical Fluid Extraction (SFE) plant. The scope of supply includes the skid-mounted plant as well as on-site installation and commissioning support. The plant will be used to extract solids for the manufacturing of products which are needed in the health care sector. As solvent, supercritical CO2 is used: A clean, non-toxic process to produce high-quality products which are free of solvent residues. This makes this technology ideal for applications with high demands concerning product purity, e.g. in the food and pharma industries, even for producing organic certified materials.
"Adapted to individual user requirements, this plant will serve two uses: for production, which primarily involves solids extraction, but also for pilot testing involving also liquids extraction," said Volkmar Steinhagen, product manager SFE plants. "We are happy to bring our decades of experience in building pharmaceutical-grade plants to meet our customer's requirements."
The plant includes extractors for solids extraction, a column for liquids extraction, separators, a buffer tank, heat exchangers, a CO2 pump, a co-solvent pump and a feed pump. Fabrication of key components as well as the pre-assembly of the plant will take place in Hagen, Germany. The installation and commissioning of the plant will be done at site. By delivering a modularized, skid-mounted solution, setup and installation efforts are minimized. This allows for a quick start of the commissioning after delivery.
Pharma-grade plants from Uhde High Pressure Technologies meet the most stringent requirements.
While standard supercritical extraction equipment is suitable for food and chemical products, the pharmaceutical industry has even higher requirements concerning materials, surfaces, prevention of dead legs, cleanability, process controls, qualification, documentation and others. Uhde High Pressure Technologies has developed their well-proven technology to fit these needs. Some examples are hygienic high pressure pipe fittings and valves, specially modified equipment like the clamp closure system for high pressure vessels, and quality-focused fabrication procedures like orbital welding of pipes. The design, fabrication and documentation of the equipment is carried out according to current Good Manufacturing Practice (cGMP), so it can be used for a wide range of processes in the pharmaceutical sector, such as particle processes, extractions and purifications in pressure ranges from 300 to 1,000 bar.
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thyssenkrupp Uhde High Pressure Technologies
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